U.S. stocks traded lower, with the Nasdaq Composite falling more than 1% on Wednesday. Here are some big stocks recording gains in today’s session.

• Scholar Rock Holding Corporation SRRK shares jumped 16.5% to $8.92. Jefferies upgraded Scholar Rock from Hold to Buy and announced a $20 price target.
• Stride, Inc. LRN climbed 16.4% to $51.81 after the company reported first-quarter results.
• GH Research PLC GHRS gained 9.8% to $7.59.
• PROG Holdings, Inc. PRG rose 9.3% to $31.14 following upbeat quarterly results.
• Anavex Life Sciences Corp. AVXL gained 9% to $5.59. Anavex Life Sciences reported a new publication in a scientific journal demonstrating the potential of ANAVEX 3-71 to prevent cognitive decline in Alzheimer's disease.
• John Bean Technologies Corporation JBT surged 9.9% to $105.80 after posting strong quarterly earnings.
• Pagaya Technologies Ltd. PGY gained 8% to $1.29 as the company said it has onboarded two new partners to its premier tech-enabled, two-sided lending network: a top five bank in the U.S. and a top four auto captive lender.
• Deutsche Bank Aktiengesellschaft DB rose 6.6% to $10.72 after the company reported a year-over-year increase in third-quarter EPS and sales results.
• The Gap, Inc. GPS climbed 6.2% to $13.18. Wells Fargo upgraded Gap from Equal-Weight to Overweight and raised the price target from $11 to $16.
• Lifezone Metals Limited LZM rose 6.2% to $9.77.
• Schnitzer Steel Industries, Inc. RDUS surged 5.5% to $25.61 following better-than-expected quarterly earnings.
• F5, Inc. FFIV rose 5% to $155.70 following upbeat quarterly results.
• Westinghouse Air Brake Technologies Corporation WAB gained 4.8% to $104.74 after the company reported third-quarter financial results and issued 2023 guidance above estimates.
• Waste Management, Inc. WM rose 6.5% to $164.75 following upbeat quarterly earnings.
• General Dynamics Corporation GD gained 4.3% to $242.98 after the company reported better-than-expected quarterly financial results.
• Microsoft Corporation MSFT shares gained 3.7% to $342.72 as the company posted stronger-than-expected results for its fiscal first quarter on Tuesday. Piper Sandler maintained Microsoft with an Overweight and raised the price target from $400 to $425.

Now Read This: Alphabet To Rally Over 33%? Here Are 10 Top Analyst Forecasts For Wednesday